What enterprises should know about The White House's new AI 'Manhattan Project' the Genesis Mission

President Donald Trump’s new “Genesis Mission” unveiled Monday, November 24, 2025, is billed as a generational leap in how the United States does science akin to the Manhattan Project that created the atomic bomb during World War II.

The executive order directs the Department of Energy (DOE) to build a “closed-loop AI experimentation platform” that links the country’s 17 national laboratories, federal supercomputers, and decades of government scientific data into “one cooperative system for research.”

The White House fact sheet casts the initiative as a way to “transform how scientific research is conducted” and “accelerate the speed of scientific discovery,” with priorities spanning biotechnology, critical materials, nuclear fission and fusion, quantum information science, and semiconductors.

DOE’s own release calls it “the world’s most complex and powerful scientific instrument ever built” and quotes Under Secretary for Science Darío Gil describing it as a “closed-loop system” linking the ...